GT (Sialyltransferase and fucosyltransferase) mutagenesis and Metabolic Engineering for the synthesis of 3‘/6‘-SL and 2‘/3-FL from human Milk

22 Aug 2019
14 Jan 2019 | 3:30pm
CeLS 01-07, CeLS Auditorium

GT (Sialyltransferase and fucosyltransferase) mutagenesis and Metabolic Engineering for the synthesis of 3‘/6‘-SL and 2‘/3-FL from human Milk

Oligosachharides in human milk(HMOs) have various useful biological functions for infant and applications in industry. Among them, sialyllactose(3’/6‘-SL) and fucosyllactose(2‘/3-FL) draw our atttention. To produce these oligosaccharides in large quantity, economic supply of CMP-Neu5Ac, highly active sialyltransferase(ST) and fucosyltransferase(FT) are keys to the success of the process development.