Tools and Strategies for Discovering Novel Enzymes in Novel Metabolic Pathways
The number of proteins in the UniProt database (>89M sequences in Release 2017_08) is increasing with a doubling time of 2.5 yrs; however, ≥50% of... Read More
Enzyme Functional Annotation: from new microbial metabolism to mammalian antiviral defense mechanisms
The vast majority of proteins have not been subjected to experimental functional annotation, and a large proportion are misannotated. We describe an integrated pipeline that... Read More
Understanding and Expanding the Photosynthetic Organisms for Terpenoid Production
Terpenoids are one of the largest classes of chemical compounds, some of them with industrial interest as nutraceuticals, biofuels, or chemical feedstock. Even though they... Read More
Visualizing Membrane Proteins Using X-ray and Electron
There are 1.7% coordinate files from membrane proteins deposited in the protein data bank. 20-30% of all ORFs genomic-wide are predicted to encode membrane proteins... Read More
Biotechnology to Help Achieve the UN’s Sustainable Development Goals
We are living in a world that is so rapidly changing with a lot of global risks. To make better state of the world, the... Read More
Innovations in Cell-Free Synthetic Biology
Cell-free transcription-translation systems were originally applied towards in vitro protein production. More recently, synthetic biology is enabling these systems to be used within a systematic... Read More
Biofilm Biology-Informed Biofilm Engineering
Biofilm represents the predominant mode of growth of microorganisms in natural, engineered and medical habitats. Microbial biofilms can be either beneficial or detrimental in different... Read More
